License: Creative Commons Attribution 4.0 International license (CC BY 4.0)
When quoting this document, please refer to the following
DOI: 10.4230/DagRep.12.9.121
URN: urn:nbn:de:0030-drops-178110
URL: http://dagstuhl.sunsite.rwth-aachen.de/volltexte/2023/17811/
Go back to Dagstuhl Reports

Findeiß, Sven ; Flamm, Christoph ; Ponty, Yann
Weitere Beteiligte (Hrsg. etc.): Sven Findeiß and Christoph Flamm and Yann Ponty

Rational Design of RiboNucleic Acids (Dagstuhl Seminar 22381)

pdf-format:
dagrep_v012_i009_p121_22381.pdf (2 MB)

Abstract

This report documents the program and outcomes of Dagstuhl Seminar 22381 "Rational Design of RiboNucleic Acids" (RNAs). The seminar covered a wide array of models, algorithmic strategies, molecular scales and modalities, all targeting in silico design of RNAs performing predefined biological functions. It consisted in a series of talks, each being allocated a generous time budget enabling frequent (welcomed!) interruptions and fruitful discussions. Applications of rational RNA design include mRNA vaccines; RNAs acting as sensors; self-replicating RNAs, relevant to RNA world/origin of life studies; populations of RNAs performing computations, e.g. through strand-displacement systems; RNA origamis forming nano-architectures through self-assembly; weakly interacting RNAs inducing the formation of droplets within cells through liquid-liquid phase separation. Those diverse applications are typically tackled by Bioinformatics-inclined scientists, contributing to distinct areas of life science and, as a result, somewhat isolated and sometimes unaware of similar pursuits in neighboring fields. The overarching goals of this meeting were to gather computational scientists from multiple fields, increase awareness of relevant efforts in distant communities, and ultimately contribute to a transversal perspective where RNA design becomes an object of study in itself.

BibTeX - Entry

@Article{findei_et_al:DagRep.12.9.121,
  author =	{Findei{\ss}, Sven and Flamm, Christoph and Ponty, Yann},
  title =	{{Rational Design of RiboNucleic Acids (Dagstuhl Seminar 22381)}},
  pages =	{121--149},
  journal =	{Dagstuhl Reports},
  ISSN =	{2192-5283},
  year =	{2023},
  volume =	{12},
  number =	{9},
  editor =	{Findei{\ss}, Sven and Flamm, Christoph and Ponty, Yann},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/opus/volltexte/2023/17811},
  URN =		{urn:nbn:de:0030-drops-178110},
  doi =		{10.4230/DagRep.12.9.121},
  annote =	{Keywords: RNA, RNA design, Inverse folding, RNA structure, mRNA design, RNA sensors, Co-transcriptional folding, Molecular evolution, Distant homology, Drug design}
}

Keywords: RNA, RNA design, Inverse folding, RNA structure, mRNA design, RNA sensors, Co-transcriptional folding, Molecular evolution, Distant homology, Drug design
Collection: DagRep, Volume 12, Issue 9
Issue Date: 2023
Date of publication: 04.04.2023

DROPS-Home | Fulltext Search | Imprint | Privacy Published by LZI